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D2

Self DW, Barnhart WJ, Lehman DA, Nestler EJ. Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists. Science. 1996 Mar 15;271(5255):1586-9.

DA drug reward D1 D2 rat Self Nestler

Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists -- Self et al. 271 (5255): 1586 -- Science コカインシーキング(priming effect)をD2受容体が促進し、D1受容体が抑制する。

Eyny YS, Horvitz JC. Opposing roles of D1 and D2 receptors in appetitive conditioning. J Neurosci. 2003 Mar 1;23(5):1584-7.

DA reward D1 D2 rat Eyny Horvitz

Opposing Roles of D1 and D2 Receptors in Appetitive Conditioning -- Eyny and Horvitz 23 (5): 1584 -- Journal of Neuroscience 長期増強はD1受容体ブロックで抑制され、D2受容体ブロックで促進されるっていうけど、じゃあD1拮抗薬のSCH23390やD2拮抗薬…

Aragona BJ, Liu Y, Yu YJ, Curtis JT, Detwiler JM, Insel TR, Wang ZNucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. Nat Neurosci. 2006 Jan;9(1):133-9. Epub 2005 Dec 4.

DA reward D1 D2 NAcc

Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds - Nature Neuroscience 動物がつがいをつくって、きっちり子孫を残すことは進化のうえで重要なんよ。人間みたいに（ほとんどが）単婚制で、子…